Episode 45
Nonmetastatic Non-Small Cell Lung Cancer — An Interview with Dr Jamie E Chaft
Featuring an interview with Dr Jamie E Chaft, including the following topics:
- Case: A man in his early 70s with a 40 to 50 pack-year history of smoking and cT2bN1 squamous cell carcinoma of the lung with PD-L1 60% treated with induction therapy and surgery (00:00)
- Available clinical data with immunotherapy in the neoadjuvant, perioperative and adjuvant settings (07:45)
- Factors in the selection of adjuvant immunotherapy, including circulating tumor DNA (11:39)
- Evolving approaches to management, including systemic therapy, surgery and radiation therapy techniques (19:28)
- Case: A woman in her early 60s with nonmetastatic non-small cell lung cancer (NSCLC) and an EGFR exon 19 deletion who is enrolled in the NeoADAURA study (24:03)
- Importance of clinical trials in the adjuvant setting (33:02)
- Data surrounding treatment in the neoadjuvant setting; key implications of the NeoADAURA study (35:41)
- Case: A man in his late 60s with a history of smoking and Stage III T4N3 NSCLC not otherwise specified with low PD-L1 expression, high tumor mutation burden, microsatellite stability and an STK11 mutation (41:34)
- Selecting patients for the NeoADAURA study treatment approach; deciding between chemoimmunotherapy and chemoradiation therapy (51:01)
